Can Peptide Improve Acne Scarring & Wrinkles


Peptides are one of the latest entrants into the world of cosmetic ingredients icons. But, do peptides work to correct skin imperfections like wrinkles and acne scars or do they just inflate the price of cosmeceuticals? To address this question, it’s important to understand the causes of skin damage and the effects of peptides on the skin.
How Do Peptide Affect the Skin

Taking a more practical look at peptides’ effect on the skin, in 2003 researchers tested a skin care product containing a combination of growth factor peptides on the skin of 14 study participants. The findings were released in the Journal of Cosmetic and Laser Surgery.

Popular Versions of Peptide Creams at Local Drug Stores

In addition to pentapeptide-3, you can also find products with “Argireline”, or acetyl hexapeptide-3, as it will appear on the ingredients panel. Argireline is a synthetic peptide manufacturer acclaim as a topical alternative to botulinum toxin injections. As a wrinkle reducer, acetyl hexapeptide-3 is based on the concept of wrinkles receptor blocking. Acetyl hexapeptide-3 mimics the actions of acetylcholine. Acetylcholine is a chemical that transmits messages between the nerves. As such, acetylcholine can influence muscle relaxation. In theory, acetyl hexapeptide-3 blocks the sodium pathway to muscles.

The presence of sodium can cause muscles tension. Once the sodium is blocked by the copycat peptide acetyl hexapeptide-3, the muscle can remain relaxed without the presence of tension induced wrinkles. And finally, while skin care shopping, you may see products that contain marine collagen. The theory here is that collagen begets more collagen, and thus increasing the skin’s thickness while reducing the appearance of wrinkles. See more.

Comparing Peptide Creams to Botox

The hottest tagline for this peptide and collagen-based cosmetics is “Better Than Botox”. Botox is the trade name for botulinum toxin type A; an FDA approved a drug designed to correct wrinkles. A study recently published in Dermatologic Surgery pitted Botox, against a placebo saline injection, and three different cosmetic products, that claimed superiority to Botox. One product contained Pentapeptide-3, the next Acetyl hexapeptide-3 and the third product contained marine collagen that utilised a patented skin delivery method.

In all, 77 women divided into groups of five participated in the study. An outside investigator measured wrinkle improvements in the skin using the Facial Wrinkle Scar scale, at weeks 4, 8 and 12 after the treatments. The independent examiner noted the most improvement with the patients treated with Botox. The examiner found a minimal difference between the placebo injection of saline and the other three wrinkle creams. In short, the effectiveness of peptide-based cosmetics depends on several items, the percentage of the peptide used in the product and the effectiveness of the peptide delivery method. A present, most studies of the efficacy of peptides are done by the product manufacturers themselves. More studies are needed to quantify the effectiveness of peptides to correct wrinkles and acne scarring. In the meantime, peptides containing cosmetics remain a hot item.


Nevertheless, if you are set on purchasing peptide-based cosmetics, there are at least two things you should do to get the most out of your product and your money. Use the cream at least twice daily (unless directed otherwise) and deeply cleanse your face with a gentle but thorough agent such as witch hazel before applying the peptide. Check out this:

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